PINK1 and steatosis: Both in vitro and in vivo studied indicate that AFB1 promotes mitophagy by increased Parkin and PTEN-induced putative kinase 1 (PINK1) through inducing the expression of COX-2, then results in lipid accumulation and steatosis, due to the fact that mitophagy disrupts the normal mitochondrial lipid metabolism function (Ren et al., 2020).