TP53 and cancer: Specifically, the obtained biological processes were mainly related to apoptosis, G2/M transition of cell cycle, viral process, protein ubiquitination, and transcription, while the affected signaling pathways mainly included PI3K-Akt signaling pathway, MAPK signaling pathway, cell cycle, pathways in cancer, viral carcinogenesis, p53 signaling pathway, and ubiquitin mediated proteolysis (Figures 3B,C; Supplementary Figure S3; Tables 2, 3).