The KEGG pathway enrichment analysis showed that the DEGs in the module were mainly enriched in the cell cycle, p53 signaling pathway, oocyte meiosis, microRNAs in cancer, etc. Since the nodes with high connectivity play an important role in maintaining the whole PPI network structure, and are an indispensable part of the network, we analyzed the topology of DEGs through the plug-in CytoNCA, and used degree >50 as the screening condition. This evidence concerns the gene TP53 and cancer.