However, it was also shown that the pro-tumor TAN N2 subset exhibits the ability to suppress the proliferation of intratumor CD8+ T cells and their IFNγ production (Coffelt and De Visser, 2016) and to induce CD8+ T cell apoptosis by secretion of TNFα and NO (Michaeli et al., 2017). Here, TNF is linked to neoplasm.