FMO5 and neoplasm: For example, the cytotoxic effect of the N1 subset is achieved through enhanced NADPH oxidase activity, which leads to the production of reactive oxygen species, causing direct tumor cell apoptosis, granule release, tumor cell sloughing, ADCC through Fc receptors, and trogoptosis (Otten et al., 2005; Hodi et al., 2010; Lohse et al., 2012; Matlung et al., 2018).