TGFB1 and neoplasm: Of note, TANs can display diverse responses to the tumor depending on the presence of different stimuli, such as type I IFN with TANs polarizing toward antitumor (N1) subset or transforming growth factor beta (TGFβ) toward pro-tumorigenic (N2) subset; (Fridlender et al., 2009; Andzinski et al., 2016; Shaul et al., 2016; Hong, 2017).