COUP-TF interacting protein 2 (Ctip2), also known as Bcl11b, is a transcription factor expressed in striatal MSNs (Desplats et al., 2008), in some areas of the hippocampus (Simon et al., 2012, 2016) and in cortical motoneurons (Leid et al., 2004; Arlotta et al., 2005; Tantirigama et al., 2016), and it was shown to bind mHTT protein in R6/1 and YAC72 transgenic HD mice (Desplats et al., 2008). This evidence concerns the gene BCL11B and Huntington disease.