Duplications, deletions, and various point mutations of SHANK3 have been identified in individuals with numerous types of brain disorders, including autism spectrum disorders (ASDs), bipolar disorder, intellectual disability, and schizophrenia, suggesting that Shank3 is critical for proper synaptic development and function (Grabrucker et al., 2011; Guilmatre et al., 2014; Monteiro and Feng, 2017; Ey et al., 2020). Here, SHANK3 is linked to Intellectual disability.