TLR4 and infection: Nevertheless, the TLR4-/- mice experienced only transient weight loss with no mortality in response to an infection and also cleared the virus by day 7 postinfection (despite having higher viral titers than wild-type mice at days 2 and 4 postinfection) [113], which has good implications for trying a TLR4 antagonist in SARS-CoV-2 infections.