Based on our proposal (see Disclosure: DOI) and Choudhury and Mukherjee [30], another recent report speculates on the hypothesis that the TLR4 signalling pathway provides opportunities for the targeting of TLR4 by antagonists in severe COVID-19 patients with cardiometabolic complications provided that the involvement of TLR4 is proven [152]. The gene discussed is TLR4; the disease is COVID-19.