Further analysis of hub genes in the HPA database showed that the protein expression levels of STAT1, CCND1, KRAS, CD80, ICAM1, ESR1, RAF1, FOSB, and DNM1 were upregulated in PDAC tissues compared with normal tissues, and the RPS6KA2 protein level was significantly decreased in PDAC tissues; however, the expression of RPS6KA2, KDM6B, and TNRC6A was not significantly different between pancreatic cancer samples and normal control tissues (Figures 7(a)–7(l)). Here, ESR1 is linked to pancreatic neoplasm.