The methylation levels of KRAS, ESR1, RAF1, RPS6KA2, and TNRC6A were significantly higher in primary tumor tissues compared with those in normal tissues, while the methylation levels of CD80 and DNM1 were significantly decreased in tumor samples than adjacent normal samples; but, there is no statistical difference in methylation levels of STAT1, CCND1, ICAM1, KDM6B, and FOSB (Figures 6(a)–6(l)). This evidence concerns the gene ESR1 and neoplasm.