Evidences show that RBP4 acts as a metabolic marker of chronic inflammatory diseases such as obesity, type 2 diabetes, and cardiovascular disease (CVD) [9–11] and has relation with the severity and prognosis of acute ischemia stroke (AIS), stable coronary artery disease (CAD), acute coronary syndrome (ACS), and atherosclerosis [12–19]. The gene discussed is RBP4; the disease is obesity due to melanocortin 4 receptor deficiency.