FOXP3 and colitis: Acetate, propionate, and butyrate promote Treg cell differentiation by inhibiting the activity of histone deacetylase (HDAC) and enhancing histone H3 acetylation at the promoter of Foxp3, thereby promoting the acetylation of Foxp3 locus, inducing the differentiation of colonic Treg cells and ameliorating the development of colitis.