To confirm these results in primary CLL cells, we quantified the abundance of SURVIVIN, cleaved caspase 3, p27kip1, phospho 53 (S15), and p21Cip1 in leukemic B cells stimulated with CpG-ODN + IL15 and treated with siMSI2 or siCTR. This evidence concerns the gene CDKN1A and B-cell chronic lymphocytic leukemia.