Both CD4_5 and CD4_7 had expression of regulatory T (Tregs) cell markers (Fig. 4c), with higher levels of FOXP3, IL2RA (CD25), CTLA4, and TNFRSF18 (GITR) in the tumor-predominant CD4_5 (Fig. 4c). This evidence concerns the gene TNFRSF18 and neoplasm.