CD4 and neoplasm: Upregulated within the tumor-infiltrating CD4+ T cells were heat shock proteins (HSPA1A and HSPA1B), Jun and FOS constituents (FOS, JUN, and JUNB), MHC-II molecules (HLA-DRB), and secreted molecules (CCL5, GZMA, and GZMK) (Fig. 4f).