In a 1:1 matched case–control study (mean age: 51.7 years) of 197 Chinese patients with hypertension and 197 without hypertension, Zhou et al.14 reported that the median serum klotho concentrations were 269.67 and 313.95 ng/L (P = 0.004) in the hypertensive and normotensive groups, respectively. This evidence concerns the gene KL and hypertensive disorder.