Prevalence of CD is high in patients with insulin dependent diabetes mellitus type 1 (DM1), chronic diarrhea, autoimmune thyroid disease (ATD), autoimmune hepatitis, Down syndrome (DS), inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), Turner syndrome (TS), and first-degree relatives (FDR) of patients with CD5,6. This evidence concerns the gene CD5 and irritable bowel syndrome.