Interestingly, Gao and coworkers reported that salicylic diamines down-regulate the expression of anti-apoptotic Bcl-xL and Bcl-2 mRNAs in cancer cells44, suggesting that they might also affect the balance between pro- and anti-apoptotic proteins more readily in PSCs than in CMs, and in this way lead to selective killing of PSCs. This evidence concerns the gene BCL2 and cancer.