In addition to ApoA-I, most of the apolipoproteins classically associated with HDLs were less abundant in COVID-19 HDL particles, including ApoA-II, ApoC-I, II, III, IV, ApoA-IV, ApoC-I, ApoJ, Apo(a), ApoE, ApoM, ApoD, ApoB100 and ApoF. The gene discussed is APOE; the disease is COVID-19.