Consistent with these data, the clinical benefit of HGF/EGF mRNA-LNP treatment in regenerating the liver is demonstrated here by the sharp reversion of steatosis as well as restoration of global liver function assessed by return to baseline levels of ALT 2 days after a single injection of HGF/EGF mRNA-LNP in the chronic CDE-mediated liver injury, and acceleration of liver repair in the acute acetaminophen-induced liver toxicity. The gene discussed is GPT; the disease is steatosis.