To determine whether extravasated LDL that has undergone oxidation is present in human placental tissue, we performed immunohistochemistry to detect ApoB, Ox-LDL and 4-HNE in a small number of placental sections from women with either pregestational type 1 diabetes (n=3) or without diabetes (n=4). The gene discussed is APOB; the disease is type 1 diabetes mellitus.