During the last decade, patient outcome has been significantly improved in both newly diagnosed MM (NDMM) and relapsed and refractory MM (RRMM) patients due to the use of novel therapeutic agents, such as proteasome inhibitors (PIs), immunomodulatory drugs (IMiDs) and monoclonal antibodies (MAbs) targeting CD38 or CS-1/SLAMF7 [2, 3], as well as autologous stem cell transplantation (ASCT) [4]. This evidence concerns the gene SLAMF7 and Miyoshi myopathy.