TNFRSF17 and Miyoshi myopathy: In preclinical studies, AFM26 potently induced NK-cell-mediated lysis of MM cells expressing low levels of BCMA at low effector: target ratios, even in presence of polyclonal IgG, suggesting that AFM26 exerts ADCC activity at low antibody concentrations in presence of IgG despite the presence of serum IgG or IgG M-protein in about half of MM patients [30].