Cocaine addiction, amphetamine addiction, and dopaminergic synapses were also significant pathways and shared altered proteins such as protein phosphatase 1 regulatory subunit 1B (Ppp1r1b), tyrosine hydroxylase (Th), and DOPA decarboxylase (Ddc), which are all associated with dopamine synthesis, except for calcium/calmodulin-dependent protein kinase type II subunit gamma (Camk2g), which is thought to be a mediator of memory by playing an important role in memory destabilization [53]. The gene discussed is TH; the disease is cocaine dependence.