Though the underlying synaptic mechanisms in PV-Pten-KO and Sst-Pten-KO mice need further investigation, our results provide behavioral evidence that deletion of Pten in either subtype of inhibitory neurons elicits autism-related phenotypes, suggesting a potential benefit from therapeutic strategies targeting either PV-neurons, Sst-neurons, or both subtypes, depending on specific alterations in behavioral phenotype. The gene discussed is PTEN; the disease is autism.