The autism-risk gene, phosphatase and tensin homolog on chromosome ten (PTEN), originally identified as a tumor suppressor gene, negatively regulates cell proliferation and growth by downregulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway [13–16]. Here, PTEN is linked to autism.