The same study observed that resveratrol decreases the protein expression of proliferation cell nuclear antigen, fibronectin, and upregulated the ratio of Bcl-2-associated X and B-cell lymphoma/leukemia 2 in vivo, as well as leiomyoma cell viability and mRNA levels of fibronectin and the protein expression of collagen type 1 and α-SMA (extracellular matrix protein marker), and protein levels of β-catenin [52]. This evidence concerns the gene PCNA and leiomyoma.