TNF and cancer: Thiazole derivatives have demonstrated remarkable anticancer potential due to the high affinity toward various biological targets involved in cancer pathogenesis, such as PRL-3, SHP-2, and JSP-1 phosphatases; tumor necrosis factor (TNFα); antiapoptotic biocomplex Bcl-XL-BH3; integrin avb3; and protein kinases Pl3K, CDK, LIM, EGFR, and VEGFR [66,67,68].