APOE and Alzheimer disease: Peng and coworkers suggest that in-depth information (from genome sequencing, brain imaging, peripheral biomarkers, and even functional assays on neurons derived from patient-specific induced pluripotent cells) in combination with demographic information (APOE genotype, age, gender, education, environmental exposure, life style, and medical history) will enable a better understanding of the disease mechanisms underlying AD and facilitate the design of personalized stage specific therapeutic intervention in AD [326].