Indeed, the expression of Epcam, which is a type I transmembrane glycoprotein, in iTS-P cells was significantly higher than that in iF cells, and it has been reported that loss of Epcam expression coincides with a gain in vimentin expression (mesenchymal marker) in all tumor cells, consistent with the first switch to the mesenchymal state [35]. Here, EPCAM is linked to neoplasm.