With RPE dysregulation being a key feature of AMD [189], the protective role of PEDF is reduced, with studies reporting a decrease in PEDF in the choroid of AMD eyes, suggesting that decreased PEDF in the choroid-BrM-RPE [190] creates a non-restrictive environment for the progression to nvAMD [191]. The gene discussed is SERPINF1; the disease is age-related macular degeneration.