NLRP3 and familial dilated cardiomyopathy: First, our results showed that the combined treatment with GLP-1RA and SGLT2i may lead to a potential novel strategy in targeting DCM, but the effects of empagliflozin and liraglutide on the myocardial ATP content, cytokine analysis, NLRP3 signaling, cardiac metabolism, and collagen expression in DCM remain unclear.