Both empagliflozin-treated DM rats and liraglutide-treated DM rats had higher ratio protein expressions of phosphorylated 5’ adenosine monophosphate-activated protein kinase α2 (pAMPKα2) to 5’adenosine monophosphate-activated protein kinase α2 (AMPKα2) compared with DM rats (Figure 2b). The gene discussed is PRKAA2; the disease is diabetes mellitus.