PKM and cancer: Post-translational modifications that reduce PKM2 activity, such as the oxidation of Cys-358 [75] and the dessuccinylation of Lys-498 [76] residues, increase the accumulation of glycolytic metabolites that promote glucose entrance into the pentose phosphate pathway, which generates reduced equivalents in the form of NADPH to clear excessive oxidant accumulation and maintain cancer cell survival.