PKM and cancer: Interestingly, red ginseng extract ginsenoside 20(S)-Rg3 has been shown to inhibit the Warburg effect and halt cancer cell growth through the lncRNA H19/miR-324-5p/PKM2 axis [351], where treatment with 20(S)-Rg3 indirectly enhanced the suppression of PKM2 by miR-324-5p.