However, while the molecular mechanisms mediating PKM2’s function in brown fat adipogenesis are yet to be determined, these findings suggest a novel role for PKM2 in regulating body mass and energy expenditure [170], which warrants additional investigation into the contribution of PKM2 to obesity, thermogenesis, glucose homeostasis, insulin resistance, and their associated metabolic disorders. The gene discussed is PKM; the disease is obesity due to melanocortin 4 receptor deficiency.