CASP3 and Ewing sarcoma: Indeed, a substantial increase of cleaved PARP and caspase-3 expression was observed for 2-APCAs-treated OS cell lines (U2-OS and SAOS-2) (Figure 6A,B, respectively), and STS cell lines: For example, A-673 Ewing’s sarcoma and HT-1080 (Figure 6C,D, respectively).