In addition to gynecological cancers, BRCA2 K3326X was investigated in the context of familial pancreatic cancer though the study of 250 patients with sporadic pancreatic cancer, 114 patients with familial pancreatic adenocarcinoma, 115 spouses of patients with pancreatic cancer as an additional environmental control, and a second control group of 125 patients with no cancer history undergoing cholecystectomy for other reasons. Here, BRCA2 is linked to cancer.