BRCA2 K3326X has been intensively studied in relation to environmental cancers, with a large-scale study of over 43,000 cancer patients and over 370,000 controls reported increased risk of small cell lung cancer (OR = 2.06) and squamous cell skin cancer (OR = 1.69), indicating that individuals with this SNP are vulnerable to cancers with environmental genotoxic risk factors [49]. The gene discussed is BRCA2; the disease is cancer.