Likewise, the glucokinase regulatory protein (GCKR) gene variant rs780094, which has been explored as a component of polygenic risk for T2DM and dyslipidemia [56] diminishes the beneficial effects of whole-grain foods on insulin homeostasis, possibly via the reported effect of GCKR variant on both triglyceride and glucose levels [27]. The gene discussed is INS; the disease is metabolic syndrome.