Furthermore, SAMMSON silencing using locked nucleic acid (LNA)-modified antisense oligonucleotides (GapmeRs) resulted in a marked reduction of cells’ clonogenic ability and in a massive cell death (independently of their NRAS, BRAF or TP53 status), as well as in an enhanced cytotoxic effects of BRAF and MEK inhibitors in melanoma cell lines and patient-derived xenograft (PDX) [46]. Here, NRAS is linked to melanoma.