CXCL8 interacted with its receptor CXCR2 on neutrophils, leading to the formation of NETs via Src and extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinases (MAPK) signaling to aggravate atherosclerosis progression in vivo [85]. The gene discussed is CXCR2; the disease is atherosclerosis.