TLR4 knockout leads to decreased level of IL-12p40 in lung homogenate supernatant 4 weeks postinfection, higher mortality and shorter survival time after intranasal inoculation with 105 or 5 × 105 CFU [84] or aerosol infection with 2000 CFU MTB [85], but the Reiling and colleagues study showed that TLR4-/- mice succumb to aerosol infection with 2000 CFU MTB with similar kinetics as WT mice [81]. Here, TLR4 is linked to infection.