Previously, 10-week treatment of adult chow-fed mice with a more broad-spectrum PI3K inhibitor (CNIO-PI3Ki, which inhibits PI3Kα, PI3Kδ and PI3Kγ) did not affect fasted blood glucose levels of chow diet fed mice, while reducing fat mass and lowering blood glucose in murine obesity models [14]. Here, PIK3CA is linked to obesity due to melanocortin 4 receptor deficiency.