Indeed, the frequency of effector memory T cells re-expressing CD45RA (TEMRA, CD45RA+ CCR7− CD27− CD28−) Vδ2+ γδ T cells, TEMRA αβCD8+, late effector memory (LEM, CD45RA− CCR7− CD27− CD28−) αβCD8+ T cells and early effector memory (EEM, CD45RA− CCR7− CD27+ CD28+) αβCD4+ conventional T cells were increased in BC samples compared to HV samples. The gene discussed is CD28; the disease is breast cancer.