TNF and neoplasm: However, these TEMRA displayed features of senescence and exhaustion, with a high expression of PD1, a key inhibitory receptor in T cells tolerance induction [56,57], as well as CD57, a canonical marker of replicative Vδ2+ γδ T cells senescence associated with impaired cytotoxic function toward tumor cells and diminished TNF-α/IFN-γ release [58,59].