CD28 and breast cancer: Indeed, the frequency of Naïve (CD45RA+ CCR7+ CD27+ CD28+) Vδ2+ γδ T cells, Naïve αβCD8+ T cells, Naïve αβCD4+ conventional T cells, central memory (CM, CD45RA− CCR7+) Vδ2+ γδ T cells, resting (CD45RA+ CCR7+ CTLA-4low ICOSlow) Tregs and Tregs expressing a marker associated with a disrupted immunosuppressive activity (DNAM1+), were increased in HV samples compared to BC samples.