The role of the TP53 pathway is well established in glioma; mutated TP53 upregulates MYC, EGFR, PNCA and downregulates p21, CD95Fas, PTEN. The cell cycle gene upregulation may originate from cancer cells or immune cells, which are prevalent in glioblastoma [13]. The gene discussed is PTEN; the disease is glioma.