In this regard, not only do the virus direct binding and functional impairment of ACE2 enzymatic function, but also epigenetic regulation of ACE2 expression in various tissues/conditions, serve as a physio-pathological mechanism underlying the COVID-19 disease complex, and further relate to blood clotting, aneurisms and chilblains in infant patients [43,44,45,46]. The gene discussed is ACE2; the disease is COVID-19.