Increased PHGDH levels and subsequent increases in de novo serine biosynthesis result in the upregulation of the cellular events fueled by the folate and methionine cycles, including increased DNA synthesis, increased biomass production, and increased methylation processes, and can also contribute to tumor stem cell differentiation (Baksh et al., 2020; Possemato et al., 2011). This evidence concerns the gene PHGDH and neoplasm.