CLCN1 and Myotonia: Since correction of myotonia is believed to occur when chloride conductance rises to only 30% of WT levels (95), and Clcn1 splicing was partially corrected as early as 3 days after ASO injection, it is not surprising that we observed partial reduction of myotonia as early as day 7 of ASO treatment and complete resolution by day 10 at higher doses.