Although previous work has suggested that other RBPs, including CELF1, HNRNP H, and RBFOX, may contribute to splicing misregulation in DM1 (73,76–79), our results indicated that Mbnl loss may account for nearly all effects on alternative splicing in the HSALR model and most of the effects on gene expression, in line with previous studies using RT-PCR or microarrays (8,36,40). Here, HNRNPH2 is linked to myotonic dystrophy type 1.