Meanwhile, miR-302b up-regulationsuppressed type I collagen and α-SMA expression and increased E-cadherin expression.Previous studies have demonstrated that collagen I, an important component ofinterstitial extracellular matrix, is up-regulated during renal fibrosis (27,28).Increased α-SMA expression and loss of E-cadherin indicates renal cells undergo EMT,which is an important part of renal fibrosis (29,30). Here, ACTA1 is linked to renal fibrosis.