The variant ERBB4 c.2513G>A is described in the COSMIC database (35) as pathogenic (score 0.99) and has already been observed in hormone receptor-positive breast cancer, large bowel adenocarcinoma, malignant melanoma, and gastroesophageal junction adenocarcinoma. This evidence concerns the gene NR4A1 and gastroesophageal junction adenocarcinoma.