PTGFRN has been shown to affect a wide range of biological processes such as fertilization [27, 28], migration [29], and accumulation of lipids in preadipocytes [30], extracellular vesicle bioactivity [31], non-alcohol fatty liver disease [32], and Alzheimer’s disease [33]. The gene discussed is PTGFRN; the disease is early-onset autosomal dominant Alzheimer disease.