KLK3 and posterior cortical atrophy: We recently published a series of patients with cT4 PCa, defined as a fixed mass by digital rectal examination (DRE) in combination with high or very high prostate-specific antigen (PSA) levels (median 37.6 ng/ml; range 2.44–284 ng/ml) in many cases (n = 39 patients with PSA ≥ 50 ng/ml)[8].