,77 A few lines of evidence implicate melanopsin as playing a role in refractive eye growth, including lack of adaptation in melanopsin-driven pupillary response in adult with myopic refractive errors,78 identification of altered Opn4 gene expression in lens-induced myopia in chicken,79 altered refractive development and increased response to form deprivation in Opn4−/− mice (preliminary data not shown), and mRGC dendrites colocalizing on dopaminergic amacrine cells to potentially modulate DA release.80 This evidence concerns the gene OPN4 and myopia.