For instance, C/EBPα could induce PPARγ expression by identifying the C/EBP effector domain of the PPARγ promoter (Wu et al. 1999), and C/EBPα may act as a positive regulator binding to fat mass and obesity associated gene (FTO) promoter and activates the gene transcription (Ren et al. 2014). The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.