For instance, C/EBPα could induce PPARγ expression by identifying the C/EBP effector domain of the PPARγ promoter (Wu et al. 1999), and C/EBPα may act as a positive regulator binding to fat mass and obesity associated gene (FTO) promoter and activates the gene transcription (Ren et al. 2014). This evidence concerns the gene CEBPA and obesity due to melanocortin 4 receptor deficiency.