Of note, COSMOS provided deeper insights into these molecular mechanisms by linking MYC activation to NFKB1. The COSMOS model suggests that MYC up‐regulates the expression of the metabolic enzyme BCAT1, potentially leading to the observed higher levels of glutamate, glutamine and reduced glutathione in ccRCC (marked as (2) in Fig 4). Here, NFKB1 is linked to nonpapillary renal cell carcinoma.