The PPI networks of the differentially methylated genes of the three comparisons were enriched in the mTOR signaling pathway, MAPK, autophagy, apoptosis, and PI3K-Akt signaling pathway, mitophagy, pancreatic, prostate, and breast cancers in addition to chronic myeloid leukemia pathways (Fig. 3g, h, and i). The gene discussed is MTOR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.