CFTR and Multiple Organ Failure: Gut ischemia and hypoxia post severe burn leads to breakdown of intestinal epithelialbarrier and enteric bacterial translocation (EBT), resulting in serious complications,such as systemic inflammatory response syndrome, sepsis and multiple organ failure.Cystic fibrosis transmembrane conductance regulator (CFTR) is known to be downregulatedby hypoxia and modulate junctional complexes, which are crucial structures maintainingthe intestinal barrier.