In summary, our study has made several findings: 1) Cisplatin induces transcription regulation factor ATF3 expression, which suppresses a variety of cytoskeleton, ECM, filopodia and adhesion related genes; 2) Suppression of transcription of FN1 by ATF3 compromises EMT and cell migration; 3) TGFβ also induces FN1 to form a positive feedback loop to maintain its expression; and 4) Cisplatin and paclitaxel, in a neoadjuvant chemotherapy setting, block cancer metastasis together by inhibiting colonization of cancer cells on the target organs and cancer growth. This evidence concerns the gene ATF3 and cancer.